Asymmetric synthesis fragmentation reactions of 2-alkyl- and 2,4- dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones. Single enantiomer preparation of Δ(α,β)-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones

Article abstract of DOI:10.1016/S0040-4039(98)00785-0

Fragmentation reactions of keto iodolactones 4 provide access to butenolides 5,2-alkyl-4-hydroxy-2-cyclohexen-1-ones 6, and butyrolactones 9. Δ(α,β)-Butenolides 5e and 5f were converted to heterocytes 14-16 by way of intramolecular cycloaddition reactions