2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities

DOI: 10.1016/S0960-894X(98)00246-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1471 - 1476 (1998)

Update date:2022-08-02

Topics:

Authors:

Koga, Yasuo

Kihara, Yoshito

Okada, Minoru

Inoue, Yoshihiro

Tochizawa, Shirou

Toga, Kazuyuki

Tachibana, Kazue

Kimura, Yukio

Nishi, Takao

Hidaka, Hiroyoshi

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Article abstract of DOI:10.1016/S0960-894X(98)00246-7

In order to search for anti-arteriostenotic agents, a series of 2(1H)- quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3- cyclopropyl-3-[(1R,2R)-2-hydroxycycyclohexyl]ureido]propoxy]-2(1H)- quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.

Full text of DOI:10.1016/S0960-894X(98)00246-7

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