2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities

DOI: 10.1016/S0960-894X(98)00246-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1471 - 1476 (1998)

Update date:2022-08-02

Topics:

Authors:

Koga, Yasuo

Kihara, Yoshito

Okada, Minoru

Inoue, Yoshihiro

Tochizawa, Shirou

Toga, Kazuyuki

Tachibana, Kazue

Kimura, Yukio

Nishi, Takao

Hidaka, Hiroyoshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00246-7

In order to search for anti-arteriostenotic agents, a series of 2(1H)- quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3- cyclopropyl-3-[(1R,2R)-2-hydroxycycyclohexyl]ureido]propoxy]-2(1H)- quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.

Full text of DOI:10.1016/S0960-894X(98)00246-7

Products guided by the article

Product name:(S)-Hydroxy-phenyl-acetic acid (1S,2S)-2-cyclopropylamino-cyclohexyl ester

Cas No:210685-45-3

R&D Labs maybe for 210685-45-3

Jinan Great Chemical Co.,Ltd.

Contact:+86-531-58668191 58668193 58668196 58661173

Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Hangzhou Chemfar Ltd.

Contact:+86-571-87859231, 87859237, 87859239

Address:1606,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China, 310053
Jiangsu Feymer Technology Co., Ltd.

Contact:+86-512-58110132

Address:Fenghuang Town, Zhangjiagang City, Jiangsu Province, China
ZUNYI CITY BEI YUAN CHEMICAL CO., LTD

website:http://www.china-beiyuan.com

Contact:+86-851-27751258

Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China
Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China

Relevant to this article

Doi:10.1016/S0040-4039(00)89511-8
(1968)
The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

Doi:10.1016/S0040-4020(97)00008-2
(1997)
New synthetic technology for the synthesis of aryl ethers: Construction of C-O-D and D-O-E ring model systems of vancomycin

Doi:10.1021/ja9636350
(1997)
Total synthesis of vancomycin - Part 1: Design and development of methodology

Doi:10.1002/(SICI)1521-3765(19990903)5:9<2584::AID-CHEM2584>3.0.CO;2-B
(1999)
New syntheses of indole phytoalexins and related compounds

Doi:10.1016/S0040-4020(98)00088-X
(1998)
Studies on 3'-quaternary ammonium cephalosporins - III. Synthesis and antibacterial activity of 3'-(3-aminopyrazolium)cephalosporins

Doi:10.1016/S0968-0896(96)00270-2
(1997)

Article Doi