Bioorganic and Medicinal Chemistry Letters p. 1471 - 1476 (1998)
Update date:2022-08-02
Topics:
Koga, Yasuo
Kihara, Yoshito
Okada, Minoru
Inoue, Yoshihiro
Tochizawa, Shirou
Toga, Kazuyuki
Tachibana, Kazue
Kimura, Yukio
Nishi, Takao
Hidaka, Hiroyoshi
In order to search for anti-arteriostenotic agents, a series of 2(1H)- quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3- cyclopropyl-3-[(1R,2R)-2-hydroxycycyclohexyl]ureido]propoxy]-2(1H)- quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.
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