Bioorganic and Medicinal Chemistry Letters p. 1471 - 1476 (1998)
Update date:2022-08-02
Topics:
Koga, Yasuo
Kihara, Yoshito
Okada, Minoru
Inoue, Yoshihiro
Tochizawa, Shirou
Toga, Kazuyuki
Tachibana, Kazue
Kimura, Yukio
Nishi, Takao
Hidaka, Hiroyoshi
In order to search for anti-arteriostenotic agents, a series of 2(1H)- quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3- cyclopropyl-3-[(1R,2R)-2-hydroxycycyclohexyl]ureido]propoxy]-2(1H)- quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.
View MoreShenzhen JYMed Technology Co.,Ltd.
website:http://www.jymedtech.com
Contact:+86-755-26612112
Address:1#8,9/F, Biomedicine innovation Industrial Park, No.14, Jinhui Road, Pingshan Sistrict, Shenzhen, China
Contact:+86-531-58668191 58668193 58668196 58661173
Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
HENAN NEW BLUE CHEMICAL CO.,LTD
website:http://www.newbluechem.com
Contact:86-371-55170693/55170694
Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Gulang Hailun Fine Chemicals Co., Ltd.
Contact:13605738876 0573-84772866
Address:No. 4 Bridge, Xinjing port, Yaozhuang Town, Jiashan County, Zhejiang, China
Doi:10.1016/S0040-4039(00)89511-8
(1968)Doi:10.1016/S0040-4020(97)00008-2
(1997)Doi:10.1021/ja9636350
(1997)Doi:10.1002/(SICI)1521-3765(19990903)5:9<2584::AID-CHEM2584>3.0.CO;2-B
(1999)Doi:10.1016/S0040-4020(98)00088-X
(1998)Doi:10.1016/S0968-0896(96)00270-2
(1997)
