European Journal of Medicinal Chemistry p. 279 - 292 (1998)
Update date:2022-08-03
Topics:
Mantegani, Sergio
Baumer, Luca
Brambilla, Enzo
Caccia, Carla
Fornaretto, Maria Gioia
McArthur, Robert Albert
Varasi, Mario
The synthesis and the structure-affinity relationship (S.A.F.I.R.) study for the 5-HT(1A) receptor sites of a novel series of 5(10→9)abeo-ergoline derivatives are presented. Most derivatives showed moderate to high affinity and selectivity for 5-HT(1A) receptor sites. The structure-affinity relationship pointed out the role of the substituent at position 8, and the outstanding importance of the reduction of the indole 2,3-double bond for achieving the highest 5-HT(1A) affinity and selectivity within the compounds presented.
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Doi:10.1002/jhet.5570350421
(1998)Doi:10.1002/zaac.200600357
(2007)Doi:10.1007/PL00013475
(1998)Doi:10.1016/S0040-4039(98)01111-3
(1998)Doi:10.1080/10426509708040505
(1997)Doi:10.1021/om980264i
(1998)