Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

DOI: 10.1016/S0960-894X(98)00232-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1391 - 1396 (1998)

Update date:2022-08-05

Topics:

Authors:

Subrahmanyam, Duvvuri

Renuka Renuka

Rao, C.V. Laxmana

Sagar, P. Sangeeta

Deevi, Dhanvanthri S.

Babu, J. Moses

Vyas Vyas

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00232-7

Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occuring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.

Full text of DOI:10.1016/S0960-894X(98)00232-7

Products guided by the article

Product name:(5R,6R,7R)-methyl 7-(hydroxymethyl)-8-oxo-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate

Cas No:211043-39-9

R&D Labs maybe for 211043-39-9

Wuhan Chemwish Technology Co., Ltd

website:http://www.chemwish.com/

Contact:+86-27-67849912

Address:Room 1311, Unit 2, Block1, Innovation Road East Lake High-tech Development Zone Wuhan, Hubei，P.R. China
Yingkou Sanzheng New Technology Chemical Industry Co., Ltd.

Contact:+86-417-2927806

Address:yingkou
Shanghai Yingrui Biopharma Co., Ltd

Contact:021-3358 8661*8003

Address:shanghai
Xi'an Yuri Solar Co. Ltd

website:http://www.p-oled.cn/

Contact:+86-29-81101199

Address:No. 1199, Dingkunchi 3rd Road, High Tech Zone, Xi'an, Shaanxi, China,710119
Weinan Rigel Pharm Co., Ltd.

Contact:+86-913-2223392

Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China

Relevant to this article

Heterocycles LXXVIII. Electrophilic substitution of 2′-phenyl-4R-2,4′-bisthiazoles

Doi:10.1007/pl00013474
(1998)
Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)

Doi:10.1016/S0968-0896(98)00029-7
(1998)
Mechanism of the Reaction of Nitriles with Alkaline Hydrogen Peroxide. Reactivity of Peroxycarboximidic Acid and Application to Superoxide Ion Reaction

Doi:10.1246/bcsj.54.793
(1981)
Coumarin 1,4-dihydropyridine derivatives

Doi:10.1016/S0968-0896(98)00037-6
(1998)
cis- and trans-2-(isocyanomethyl)-5,5-dimethyl-2-oxo-4-phenyl-1,3,2-dioxaphosphorinane - Synthesis and structure of the first chiral isocyanomethylphosphonate synthons

Doi:10.1002/(SICI)1099-0690(199808)1998:8<1511::AID-EJOC1511>3.0.CO;2-G
(1998)
Conformationally constrained substance P analogues: The total synthesis of a constrained peptidomimetic for the Phe⁷-Phe⁸ region

Doi:10.1021/jo991649t
(2000)

Article Doi