
Tetrahedron Letters p. 4789 - 4792 (1998)
Update date:2022-08-03
Topics:
Clive, Derrick L. J.
Yeh, Vince S. C.
(S)-Pyroglutamic acid was converted into the (phenylthio)acetylene 14, which undergoes radical cyclization to the 7-azabicyclo[2.2.1]heptane 15. Ozonolysis then affords ketone 4, a synthetic precursor of (-)-epibatidine.
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