Simple fragment syntheses of all four isomers of the spermine alkaloid kukoamine

Article abstract of DOI:10.1016/S0040-4039(98)00940-X

All four isomers of the spermine alkaloid kukoamine were unambiguously prepared through diacylation with O,O'-dibenzylcasseyl chloride of suitably protected (benzyl and/or trityl groups) spermine derivatives, assembled on solid and/or in liquid phase using β-alanine and γ-aminobutyric acid, followed by simultaneous N- and O- deprotection and double bond reduction using catalytic hydrogenation.