A vinylogous urethane approach towards the synthesis of okadaic acid. Construction of the C1-C8 fragment. Part I

DOI: 10.1016/S0040-4039(98)00971-X

Source and publish data:

Tetrahedron Letters p. 4971 - 4974 (1998)

Update date:2022-08-04

Topics:

Authors:

Dankwardt, Sharon M.

Dankwardt, John W.

Schlessinger, Richard H.

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Article abstract of DOI:10.1016/S0040-4039(98)00971-X

A vinylogous urethane approach is utilized to synthesize the C1-C8 fragment of okadaic acid. The key steps include an asymmetric alkylation, a hydroxyl directed iodocarbonate cyclization and a stereoselective cyanohydrin formation.

Full text of DOI:10.1016/S0040-4039(98)00971-X

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