1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists

DOI: 10.1021/jm990044m

Source and publish data:

Journal of Medicinal Chemistry p. 2621 - 2632 (1999)

Update date:2022-08-04

Topics:

Authors:

Murakami, Yasushi

Hara, Hirokazu

Okada, Tetsuo

Hashizume, Hiroshi

Kii, Makoto

Ishihara, Yasunobu

Ishikawa, Michio

Shimamura, Mayumi

Mihara, Shin-Inchi

Kato, Goro

Hanasaki, Kohji

Hagishita, Sanji

Fujimoto, Masafumi

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Article abstract of DOI:10.1021/jm990044m

A novel series of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Chemical modification of the R₁ and R₃ substitue

Full text of DOI:10.1021/jm990044m

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