Highly enantioselective synthesis of cyclic and functionalized α-amino acids by means of a chiral phase transfer catalyst

Article abstract of DOI:10.1016/S0040-4039(98)01067-3

The chiral quaternary ammonium salt 1 serves as phase transfer catalyst for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral α amino acids with enantioselectivities as high as 200:1 in alkylation and Michael addition reactions.