A formal synthesis of (+)-brefeldin A

DOI: 10.1016/S0040-4039(98)01078-8

Source and publish data:

Tetrahedron Letters p. 5377 - 5380 (1998)

Update date:2022-08-03

Topics:

Authors:

Suh, Young-Ger

Jung, Jae-Kyung

Suh, Byung-Chul

Lee, Young-Choon

Kim, Soon-Ai

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Article abstract of DOI:10.1016/S0040-4039(98)01078-8

A formal synthesis of (+)-brefeldin A has been achieved via stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain. The highly advanced intermediate 2 has been synthesized from the known Weinreb amide in 19% overall yield of 11 steps.

Full text of DOI:10.1016/S0040-4039(98)01078-8

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Product name:(2S,4S,6R)-6-[((Z,6S)-6-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-1-heptenyl)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methanol

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