
Tetrahedron p. 133 - 140 (1999)
Update date:2022-07-30
Topics:
Yue, Xiangjun
Lan, Jiong
Li, Jing
Liu, Zuosheng
Lin, Yulin
The first total synthesis of (+/-)-Sinulariol-B, a marine cembrandiol, was achieved in ten steps and ca. 10 percent overall yield from E-geraniol (8). The key steps were the coupling of sulfone 7 with allylic chloride 6 and the macrocyclization of precursor 5 by sulfone- and thioether-stabilized carbanionic alkylations, respectively.
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