Tetrahedron Letters p. 7163 - 7166 (1998)
Update date:2022-09-26
Topics:
Hale, Karl J.
Jogiya, Neha
Manaviazar, Soraya
The first enantiospecific total synthesis of (3S,5S)-hydroxypiperazic acid 1 is described. The synthesis begins from D-mannitol and exploits a tandem electrophilic hydrazination/nucleophilic cyclisation reaction to assemble the hexahydropyridazine ring system.
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