Bioorganic and Medicinal Chemistry Letters p. 2345 - 2350 (1998)
Update date:2022-08-03
Topics:
An, Haoyun
Haly, Becky D.
Cook, P. Dan
Four novel unsymmetric piperazinyl polyazacyclophane scaffolds 1-4 were synthesized in high yields by an efficient cyclization strategy. Twenty-six libraries 12-37 (total 16000 compounds) were generated by a solution-phase combinatorial approach from 1-4 and thirty-eight functional groups. Potent antibacterial and HIV-1 tat/TAR protein-RNA disrupting activities were discovered.
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Doi:10.1016/S0022-1139(00)81324-X
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