Tetrahedron Letters (2019)
Update date:2022-08-05
Topics:
Qin, Shuanglin
Luo, Yunhao
Sun, Yue
Tian, Le
Jiang, Shende
yan, Jun
Yang, Guang
In the present study, an inexpensive but efficient Iron(III) and Copper(II) co-catalyst without ligands catalyzed arylation of sulfinamides with aryl iodide was primarily reported. In brief, in the presence of Fe(NO3)3·9H2O, CuO and K3PO4, the highly selective C–N cross coupling of several sulfinamides and aryl iodides was achieved in high chemical yield, while the aryl chlorides and bromides could not yield coupling products. It is noteworthy that through the arylation of chiral tert-butanesulfinamide with aryl iodides, N-aryl tert-butanesulfinamides are provided without racemization, even in gram-scale. The possible mechanism was that This oxidative addition process between copper catalyst and aryl-iodides might be significantly accelerated by active Fe(III) species. Moreover, using this synthetic method, a facile and efficient access was developed for the derivatives of N-phenyl sulfinamides, which might help to develop new drug molecules and material chemicals.
View MoreContact:86-513-84128750/13773795976
Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
Jiangxi Global Natural Spice Co., Ltd.
Contact:+86-796-8106598
Address:No.89, Wenshan Road,South Industrial Park, Jishui County,Jiangxi Province
Contact:86-571-61063068
Address:LINAN
NANCHANG QINZHI SCI&TEC.CO.,LTD
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Shanghai Kefu Chemical Co.,Ltd.
Contact:+86-21-34616196
Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Doi:10.1007/PL00010114
(1998)Doi:10.1016/S0277-5387(98)00103-X
(1998)Doi:10.1080/00397919908086455
(1999)Doi:10.1021/ol990761a
(1999)Doi:10.1039/j39700002266
(1970)Doi:10.1016/0040-4039(90)87038-2
(1990)