Tetrahedron Letters p. 8313 - 8316 (1998)
Update date:2022-07-29
Topics:
Watanabe, Hiroyuki
Watanabe, Hidenori
Kitahara, Takeshi
The convergent total synthesis of (-)-pironetin using a chiral building block, (1S, 5S, 6R)-5-hydroxybicyclo[4.1.0]heptan-2-one 5 is described. Both the dithiane 4 and the epoxide 2 with proper substituents were employed as coupling partners to construct the whole carbon skeleton 15, which was converted to pironetin 1 in a few steps.
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