Kinetics of Hydrolysis of Some New Heterocyclic Azomethines

Article abstract of DOI:10.1007/BF00646717

Kinetics of base hydrolysis of new heterocyclic azomethines derived from active methyl quaternary salts and aromatic nitroso compounds were investigated in the presence of 70percent (wt/wt) water-methanol.The base hydrolysis of these compounds is strictly first-order with respect to OH^- and azomethine.The rate determining step is suggested to be the attack of the hydroxide ion on the free base.Effects of water content and nature of organic hydroxylic solvent have been studied.It is concluded that specific solute-solvent interactions through dispersion forces play a major role in the base hydrolysis rate of the azomethines investigated.The effect of pH (2.98 - 12.24) on hydrolysis rates of compounds having a diethylamino substituent in the presence of 30percent methanol has been studied.In acidic media, the rate determining step is probably the water attack on the protonated substrate.