Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation.

DOI: 10.1016/S0960-894X(99)00212-7

Source and publish data:

Bioorganic and medicinal chemistry letters p. 1433 - 1436 (1999)

Update date:2022-08-04

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Authors:

Suh Suh

Lee Lee

Kim Kim

Han Han

Kim Kim

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Article abstract of DOI:10.1016/S0960-894X(99)00212-7

The first total syntheses of (+/-)-shinflavanone and its structural analogues were achieved. (+/-)-Shinflavanone, appears to be a strong inhibitor of bone resorption pits formation by osteoclast-like cell induced by 1alpha, 25-dihydroxy vitamine D3 (IC50 = 0.70 microg/mL).

Full text of DOI:10.1016/S0960-894X(99)00212-7

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