Application of the Pd-catalyzed heteroarylation to the synthesis of 5- (indol-2'-yl)pyridin-2-one and 5-(indol-2'-yl)pyran-2-one

Article abstract of DOI:10.1016/S0040-4020(98)00858-8

The synthesis of 5-(indol-2'-yl)pyridin-2-ones and 5-(indol-2'-yl)pyran- 2-one by Pd-catalyzed reactions is described. The best results are obtained using 2-indolylstannanes or 2-indolylzinc halides to be coupled with 5- bromopyridin-2-ones or 5-bromopyran-2-one in the presence of Pd(PPh₃)₄ as catalyst. Other Pd-catalyzed reactions are discussed.