Inhibition of Myeloperoxidase Release from Rat Polymprphonuclear Leukocytes by a Series of Azachalcone Derivatives

DOI: 10.1021/jm00051a013

Source and publish data:

Journal of Medicinal Chemistry p. 4357 - 4362 (1994)

Update date:2022-08-05

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Authors:

Edwards, Michael L.

Stemerick, David M.

Sabol, Jeffrey S.

Diekema, Keith A.

Dinerstein, Robert J.

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Article abstract of DOI:10.1021/jm00051a013

A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes by fMLP.The compounds were found to interfere with cellular uptake of extracellular calcium.Structure-activity relationships are

Full text of DOI:10.1021/jm00051a013

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