Synthesis of anti-rheumatic agent epoxyquinomicin B

DOI: 10.1016/S0960-894X(98)00529-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2945 - 2948 (1998)

Update date:2022-08-05

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Authors:

Matsumoto, Naoki

Iinuma, Hironobu

Sawa, Tsutomu

Takeuchi, Tomio

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Article abstract of DOI:10.1016/S0960-894X(98)00529-0

Anti-rheumatic agent (±)-epoxyquinomicin B was synthesized for a 22% overall yield in eight steps from commercially available 3-hydroxy-4- nitrobenzaldehyde via the intermediate quinone 6 prepared by selective phenol oxidation of 5 by use of Fremy's salt as the key step.

Full text of DOI:10.1016/S0960-894X(98)00529-0

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