Synthesis and comparative evaluation of two antiviral agents: β-L- Fd4C and β-D-Fd4C

Article abstract of DOI:10.1016/S0960-894X(98)00599-X

The synthesis of β-D-Fd₄C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of β-D-Fd₄C was compared with that of β-L-Fd₄C and 3TC (Lamivudine). Of the three agents compared, β-L-Fd₄C was found to be the most potent antiviral agent.