Simple methods for the labelling of N-methyl amines using isotopically labelled methyl iodide

DOI: 10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 1127 - 1143 (1998)

Update date:2022-08-04

Topics:

Authors:

Fellows, Ian

Carr, Richard M.

DeBoeck, Nigel

Montgomery, Stephen

Waterhouse, Ian

Sutherland, Derek R.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

Methods for the synthesis of isotopically labelled N-methyl amines using the target amine and isotopically labelled methyl iodide in a quaternisation/dequaternisation strategy are described. The method has been further refined to allow the synthesis of such amines without any isotopic dilution.

Full text of DOI:10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9

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