1,3-asymmetric induction in the intramolecular [2+2] cycloaddition of alkene-keteniminium salts. Synthesis of (+)-gibberellic acid key intermediate

Article abstract of DOI:10.1016/S0040-4039(98)02228-X

Optically active bicyclo[4.2.0]octan-7-ones were synthesized by stereoselective intramolecular. [2+2] cycloaddition of alkene-keteniminium salt derived from L-glutamic acid, based on 1,3-asymmetric induction. Synthetic application toward (+)-gibberellic acid key intermediate was also described.