Bioorganic and Medicinal Chemistry Letters p. 3371 - 3374 (1998)
Update date:2022-07-30
Topics:
Hatanaka, Toshihiro
Fujita, Koichi
Ohsumi, Koji
Nakagawa, Ryusuke
Fukuda, Yumiko
Nihei, Yukio
Suga, Yasuyo
Akiyama, Yukio
Tsuji, Takashi
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.
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Doi:10.1139/v69-245
(1969)Doi:10.1016/S0957-4166(98)00455-8
(1998)Doi:10.1039/a807108j
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(2019)Doi:10.1016/S0040-4039(98)02694-X
(1999)
