Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity

DOI: 10.1016/S0960-894X(98)00622-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3371 - 3374 (1998)

Update date:2022-07-30

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Authors:

Hatanaka, Toshihiro

Fujita, Koichi

Ohsumi, Koji

Nakagawa, Ryusuke

Fukuda, Yumiko

Nihei, Yukio

Suga, Yasuyo

Akiyama, Yukio

Tsuji, Takashi

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Article abstract of DOI:10.1016/S0960-894X(98)00622-2

A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.

Full text of DOI:10.1016/S0960-894X(98)00622-2

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