A novel thiol protecting group: A 2-thioquinoline sulfide as a masked sulfhydryl moiety

DOI: 10.1016/S0040-4039(98)02694-X

Source and publish data:

Tetrahedron Letters p. 1467 - 1470 (1999)

Update date:2022-07-30

Topics:

Authors:

Zhang, Jiancun

Matteucci, Mark D.

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Article abstract of DOI:10.1016/S0040-4039(98)02694-X

2-Thioquinoline sulfide was developed as a masked sulfhydryl entity. It is introduced through facile S(N)2 displacement reactions and is stable to a variety of reaction conditions including acids, bases and nucleophiles. It is readily unmasked using the mild treatment of sodium cyanoborohydride in acetic acid.

Full text of DOI:10.1016/S0040-4039(98)02694-X

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