Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues

DOI: 10.1016/S0960-894X(98)00604-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3331 - 3334 (1998)

Update date:2022-08-04

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Authors:

Nakajima, Noriyuki

Enomoto, Takeshi

Matsuura, Nobuyasu

Ubukata, Makoto

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Article abstract of DOI:10.1016/S0960-894X(98)00604-0

Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on src(ts)NRK cells than 2 and 3.

Full text of DOI:10.1016/S0960-894X(98)00604-0

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