Bioorganic and Medicinal Chemistry Letters p. 3331 - 3334 (1998)
Update date:2022-08-04
Topics:
Nakajima, Noriyuki
Enomoto, Takeshi
Matsuura, Nobuyasu
Ubukata, Makoto
Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on src(ts)NRK cells than 2 and 3.
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