Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues

DOI: 10.1016/S0960-894X(98)00604-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3331 - 3334 (1998)

Update date:2022-08-04

Topics:

Authors:

Nakajima, Noriyuki

Enomoto, Takeshi

Matsuura, Nobuyasu

Ubukata, Makoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00604-0

Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on src(ts)NRK cells than 2 and 3.

Full text of DOI:10.1016/S0960-894X(98)00604-0

Products guided by the article

Product name:(E)-N-[(S)-1-Methoxymethoxymethyl-2-((R)-methylsulfanylmethanesulfinyl)-ethyl]-3-phenyl-acrylamide

Cas No:220323-14-8

R&D Labs maybe for 220323-14-8

ChengduChroma-BiotechCo.,Ltd.

Contact:86-28-61993785

Address:No.70-13-21, North Section, Erhuan
Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian
Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
shanghai hekang chemical co.ltd

Contact:021-54173790

Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
jintan yufan Medicine Raw materials Co.,Ltd.(expird)

Contact:86-519-82808282

Address:6th,Jincheng Huangzhuang

Relevant to this article

Synthesis, structural characterization, and bonding analysis of (η⁴-1-azadiene)Fe(CO)₃ complexes: Consequences of the electronic structure on molecular and crystal properties

Doi:10.1021/om980415h
(1999)
Doi:10.1007/BF01031773
()
Synthesis of well-defined rod-coil block copolymers containing trifluoromethylated poly(phenylene oxide)s by chain-growth condensation polymerization and atom transfer radical polymerization

Doi:10.1002/pola.23859
(2010)
Fluorine-substitution in cholesteryl ester transfer protein inhibitors (CETP-inhibitors) - Biology, chemistry, SAR, and properties

Doi:10.2533/000942904777678082
(2004)
Tuning stereoselection in Tethered Biginelli condensations. Synthesis of cis- or trans-1-oxo- and 1-iminohexahydropyrrolo[1,2-c]pyrimidines

Doi:10.1021/jo981972g
(1999)
Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors

Doi:10.1016/j.bmcl.2007.08.020
(2007)

Article Doi