Studies on stereochemistry of theonezolides a ~ C1: Determination of absolute stereochemistry of the C-4 ~ C-17 fragment

Article abstract of DOI:10.1016/S0040-4020(98)00190-2

The absolute stereochemistry of the C-4 ~ C-17 fragment of theonezolides A ~ C (1 ~ 3) was established as 8S, 10R, 14S, 16S on the basis of synthesis of the two diastereomers (4a and 4b) suggested from model studies and comparison of their spectral and optical data with those of natural specimen (4) obtained from ozonolysis of 1 ~ 3.