Facile synthesis of a phosphotriester intermediates for solution-phase preparation of oligonucleotide phosphorothioates

Article abstract of DOI:10.1246/cl.1999.39

Fully protected 2'-deoxynucleoside phosphorothioate triester derivatives, which are key starting materials for the large-scale solution-phase preparation of phosphorothioate oligonucleotides, were easily synthesized by a new method starting from common, fully protected 2'-deoxynucleosides.