Facile synthesis of a phosphotriester intermediates for solution-phase preparation of oligonucleotide phosphorothioates

DOI: 10.1246/cl.1999.39

Source and publish data:

Chemistry Letters p. 39 - 40 (1999)

Update date:2022-08-04

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Authors:

Miyashita, Takanori

Mori, Kenya

Shinozuka, Kazuo

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Article abstract of DOI:10.1246/cl.1999.39

Fully protected 2'-deoxynucleoside phosphorothioate triester derivatives, which are key starting materials for the large-scale solution-phase preparation of phosphorothioate oligonucleotides, were easily synthesized by a new method starting from common, fully protected 2'-deoxynucleosides.

Full text of DOI:10.1246/cl.1999.39

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