Heterocycles p. 2601 - 2610 (1998)
Update date:2022-08-05
Topics:
Saladino, Raffaele
Stasi, Luigi
Volpe, Gabriele
Nicoletti, Rosario
Botta, Maurizio
Dimethylphenylsilyllithium (PhMe2SiLi) reacts with 5-substituted 1,3-dimethyluracils by selective addition at the electrophilic C-6 position of the uracil ring to give the corresponding 6-dimethylphenylsilyl-5,6-dihydrouracil derivatives. The reaction of PhMe2SiLi with 6-substituted 1,3-dimethyluracils showed a different selectivity, and an unusual addition at the C-5 position was observed. This synthetic procedure appears to be an efficient entry to a new class of highly functionalized 5,6-dihydro-1,3-dimethyluraciIs characterized by the presence of a silicon substituent selectively introduced at the C-5 and C-6 positions of the uracil ring.
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Doi:10.1021/jm980605u
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