
Chemical and Pharmaceutical Bulletin p. 1164 - 1166 (1999)
Update date:2022-08-05
Topics:
Akita, Hiroyuki
The enantioselective hydrolysis of (±)-4-(1-acetoxyethyl)-N- (cyclohexylcarbamoyl)-benzenesulfonamides 3 with lipase Amano P from Pseudomonas sp. in a water-saturated solvent gave (R)-4-(1-hydroxyethyl)-N- (cyclohexylearbamoyl)benzenesulfonamide 2 (39%, >99% ee) and unchanged (S)-3 (50%, 62% ee). On the other hand, enantioselective esterification of (±)-2 with lipase Amano P in the presence of vinyl acetate provided (R)-3 (41%, >99% ee) and unchanged (S)-2 (46%, 78% ee).
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Doi:10.1016/S0040-4020(98)01211-3
(1999)Doi:10.1016/S0040-4020(98)01222-8
(1999)Doi:10.1016/S0040-4039(98)02585-4
(1999)Doi:10.1016/j.cclet.2019.12.040
(2020)Doi:10.1016/j.carres.2016.09.015
(2016)Doi:10.1016/S0960-894X(98)00706-9
(1999)