Nucleosides and nucleotides. 183. Synthesis of 4'α-branched thymidines as a new type of antiviral agent

DOI: 10.1016/S0960-894X(99)00010-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 385 - 388 (1999)

Update date:2022-08-05

Topics:

Authors:

Sugimoto, Isamu

Shuto, Satoshi

Mori, Shuichi

Shigeta, Shiro

Matsuda, Akira

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Article abstract of DOI:10.1016/S0960-894X(99)00010-4

A series of 4'αr-branched thymidines was synthesized and evaluated as potential antiviral agents. 4'-Ethylthymidine (3), 4'-ethenylthymidine (5), and 4'-ethynylthymidine (6) exhibited potent anti-HSV-1 and anti-HIV-1 activities with no significant cytotoxicity.

Full text of DOI:10.1016/S0960-894X(99)00010-4

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