Nucleosides and nucleotides. 183. Synthesis of 4'α-branched thymidines as a new type of antiviral agent

DOI: 10.1016/S0960-894X(99)00010-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 385 - 388 (1999)

Update date:2022-08-05

Topics:

Authors:

Sugimoto, Isamu

Shuto, Satoshi

Mori, Shuichi

Shigeta, Shiro

Matsuda, Akira

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00010-4

A series of 4'αr-branched thymidines was synthesized and evaluated as potential antiviral agents. 4'-Ethylthymidine (3), 4'-ethenylthymidine (5), and 4'-ethynylthymidine (6) exhibited potent anti-HSV-1 and anti-HIV-1 activities with no significant cytotoxicity.

Full text of DOI:10.1016/S0960-894X(99)00010-4

Products guided by the article

Product name:1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-chloro-vinyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:221272-69-1

R&D Labs maybe for 221272-69-1

HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Contact:+86-186-02659358

Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
Shanghai Run-Biotech Co., Ltd.

website:http://www.run-biotech.com

Contact:+86-21-31576854/57171705 / 57171706

Address:second floor, building 3, No.999, jiangyue Road, minghang District, Shanghai, China
Suzhou Sibian Chemical Technology Co., Ltd

website:http://www.sibianpharm.com

Contact:+8618169181984,+8618013186906

Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Changzhou Kingyo Chemical Corporation Ltd.

website:http://www.kingyochem.com

Contact:+86-519-85105717

Address:19# Wuqing North Road, Changzhou , Jiangsu, China
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd

Contact:0086-10-64430626

Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.

Relevant to this article

Construction of polysubstituted olefins through Ni-Catalyzed direct activation of Alkenyl C-O of substituted alkenyl acetates

Doi:10.1002/chem.200902785
(2010)
Design and synthesis of novel electroactive 2,2′:5′,2″-terthiophene monomers including oxyethylene chains for solid-state flexible energy storage applications

Doi:10.1016/j.electacta.2021.138662
(2021)
Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: The first asymmetric cross-benzoin condensation

Doi:10.1021/ja0271476
(2002)
Identification of a selective small molecule inhibitor of breast cancer stem cells

Doi:10.1016/j.bmcl.2012.01.035
(2012)
The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes

Doi:10.1016/j.tet.2016.12.028
(2017)
Lewis acid promoted hetero [2 + 2] cycloaddition reactions of aldehydes with 10-propynyl-9(10h)-acridone. A highly stereoselective synthesis of acrylic acid derivatives and 1,3-dienes using an electron deficient variant of ynamine

Doi:10.1021/ol990211c
(1999)

Article Doi