A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives

DOI: 10.1016/S0040-4039(98)80042-7

Source and publish data:

Tetrahedron Letters p. 143 - 146 (1999)

Update date:2022-08-04

Topics:

Authors:

Allin, Steven M.

Northfield, Christopher J.

Page, Michael I.

Slawin, Alexandra M. Z.

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Article abstract of DOI:10.1016/S0040-4039(98)80042-7

A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as h

Full text of DOI:10.1016/S0040-4039(98)80042-7

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