Synthesis of phosphonate analogues of myo-inositol phospholipids

DOI: 10.1016/S0040-4039(00)92129-4

Source and publish data:

Tetrahedron Letters p. 955 - 958 (1991)

Update date:2022-08-04

Topics:

Authors:

Dreef Dreef

Elie Elie

Van Der Marel

Van Boom

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Article abstract of DOI:10.1016/S0040-4039(00)92129-4

The phosphonate analogues I and II of Ptdlns and Ptdlns[4]P, respectively, were prepared by alkylation of the α-lithio anion of a properly protected D-myo-inositol methylphosphonate diester with 1,2-isopropylidene-sn-glycerol 3-trifluoromethanesulfonate, followed by protective group manipulation and deprotection.

Full text of DOI:10.1016/S0040-4039(00)92129-4

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