Synthesis and biological properties of new 1β-methylcarbapenems

DOI: 10.1016/S0960-894X(98)00270-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1607 - 1612 (1998)

Update date:2022-08-02

Topics:

Authors:

Shin, Kye Jung

Yoo, Kyung Ho

Kim, Dong Jin

Park, Sang Woo

Ko, Bong Suck

Lee, Sang Joo

Huh, Jae Doo

Park, Seung Yong

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Article abstract of DOI:10.1016/S0960-894X(98)00270-4

The synthesis and biological activity of the novel series of 1β- methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R²=NH₂) showed an excellent and a broad spectrum as well as high renal DHP- I stability. It also possessed good in vivo efficacy and high safety.

Full text of DOI:10.1016/S0960-894X(98)00270-4

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