Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

Article abstract of DOI:10.1016/S0040-4020(99)00042-3

Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected β-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a 'one-pot' preparation of 2 from 3 are also described.