Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part II: Synthesis of side-chain-labeled [14C]atorvastatin

DOI: 10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 129 - 133 (1999)

Update date:2022-09-26

Topics:

Authors:

Lee, Helen T.

Woo, Peter W. K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

[¹⁴C]Atorvastatin was synthesized in a ten-step sequence with an overall yield of 5.7%. The label was introduced as sodium [1-¹⁴C]acetate, which was converted via the acid chloride to the (S)-2-hydroxy-1,2,2-triphenylethyl ester 4. C

Full text of DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

Products guided by the article

Product name:(R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxy-3-oxo-[3-14C]heptanoic acid tert-butyl ester

Cas No:222406-73-7

R&D Labs maybe for 222406-73-7

WUHAN WELLSONG INT'L CO.,LTD

Contact:+86-27-85733560

Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
Acorn PharmaTech Co., Ltd

Contact:86-25-58619180

Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
SINFACHEM LIMITED

Contact:86-25-84683399

Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
NanJing Rate Biochemicals CO., LTD

Contact:+86-25-84931986

Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China
Hubei Vanz Pharm Co.,Ltd

website:http://www.vanzpharm.com/en/index.html

Contact:86-27-84492310

Address:FANHU INDUSTRY PARK

Relevant to this article

1,4-Naphthoquinone disulfides and methyl sulfides: Self-assembled monolayers on gold substrates

Doi:10.1021/jo981185j
(1999)
Synthesis of a new family of N-aryl lactams active on chemesthesis and taste

Doi:10.1002/ejoc.200500677
(2006)
Doi:10.1007/BF00905002
()
Enantioselective synthesis of β-hydroxy-α-amino acid esters by aldol coupling using a chiral quaternary ammonium salt as catalyst

Doi:10.1016/S0040-4039(99)00636-X
(1999)
Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4- chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4- chlorophenyl)pentanoic acid

Doi:10.1021/jm990076+
(1999)
Doi:10.1021/jm00304a005
(1969)

Article Doi