Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part II: Synthesis of side-chain-labeled [14C]atorvastatin

DOI: 10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 129 - 133 (1999)

Update date:2022-09-26

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Authors:

Lee, Helen T.

Woo, Peter W. K.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

[¹⁴C]Atorvastatin was synthesized in a ten-step sequence with an overall yield of 5.7%. The label was introduced as sodium [1-¹⁴C]acetate, which was converted via the acid chloride to the (S)-2-hydroxy-1,2,2-triphenylethyl ester 4. C

Full text of DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

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