Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part II: Synthesis of side-chain-labeled [14C]atorvastatin

Article abstract of DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

[¹⁴C]Atorvastatin was synthesized in a ten-step sequence with an overall yield of 5.7%. The label was introduced as sodium [1-¹⁴C]acetate, which was converted via the acid chloride to the (S)-2-hydroxy-1,2,2-triphenylethyl ester 4. C