Tetrahedron Letters p. 2239 - 2242 (1999)
Update date:2022-09-26
Topics:
Ratz, Andrew M.
Weigel, Leland O.
A five step synthesis of thiotomoxetine (2) is described. Installation of the aryl ether was accomplished using a highly efficient S(N)Ar fragment coupling between amino alcohol (4) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a selective reduction of the arylsulfoxide moiety.
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Doi:10.1055/s-1999-3437
(1999)Doi:10.1021/jo982256h
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(1999)Doi:10.1248/cpb.47.394
(1999)Doi:10.1016/j.antiviral.2017.01.006
(2017)
