N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

DOI: 10.1016/S0960-894X(98)00720-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 249 - 254 (1999)

Update date:2022-08-04

Topics:

Authors:

Auberson, Yves P.

Acklin, Pierre

Bischoff, Serge

Moretti, Robert

Ofner, Silvio

Schmutz, Markus

Veenstra, Siem J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00720-3

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine- binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsa

Full text of DOI:10.1016/S0960-894X(98)00720-3

Products guided by the article

Product name:[(R)-1-(Benzyloxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid dimethyl ester

Cas No:223647-45-8

R&D Labs maybe for 223647-45-8

Taizhou volsen chemical Co., Ltd

website:http://www.volsenchem.com

Contact:+86-576-88869393

Address:Jiaojiang District, Taizhou, Zhejiang, China.
Onlychem (Jinan)Biotech Co.,Ltd

Contact:86-531-83175885

Address:No. 44, Honglou South Road, Jinan,China
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Shanghai Hanhong Scientific Co.,Ltd.

website:http://www.chemvia.com

Contact:+86-21-64541543,54280654,13918533501

Address:Jiachuan Road 245
Jiangxi Province Bethel Pharmaceutical Co., Ltd.

Contact:+86-795-259 3456 ，+86-15957688008 13566650571

Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province

Relevant to this article

Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4- (isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2-carbamates, and related derivatives

Doi:10.1021/jm00076a012
(1993)
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

Doi:10.1021/jacs.5b11814
(2015)
New findings in photochemistry of p-nitrophenyl azide in the presence of an amine: Generation and trapping of enamines

Doi:10.1246/cl.1999.597
(1999)
Application of neutral iridium(I) N-heterocyclic carbene complexes in ortho-directed hydrogen isotope exchange

Doi:10.1002/jlcr.3084
(2013)
Reaction of aminocarbene complexes of chromium with alkynes. 2. Intramolecular insertions leading to polycyclic lactams

Doi:10.1021/ja00076a015
(1993)
Electrostatic and electrophilic catalysis in the reductive cleavage of alkyl aryl ethers. The influence of ion pairing on the regioselectivity

Doi:10.1021/jo991059v
(2000)

Article Doi