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N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

DOI: 10.1016/S0960-894X(98)00720-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 249 - 254 (1999)

Update date:2022-08-04

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Authors:

Auberson, Yves P.Auberson, Yves P.

Acklin, PierreAcklin, Pierre

Bischoff, SergeBischoff, Serge

Moretti, RobertMoretti, Robert

Ofner, SilvioOfner, Silvio

Schmutz, MarkusSchmutz, Markus

Veenstra, Siem J.Veenstra, Siem J.

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Article abstract of DOI:10.1016/S0960-894X(98)00720-3

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine- binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsa

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Full text of DOI:10.1016/S0960-894X(98)00720-3

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Product name:[(R)-1-(Benzyloxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid dimethyl ester

Cas No:223647-45-8

223647-45-8

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