N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

DOI: 10.1016/S0960-894X(98)00720-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 249 - 254 (1999)

Update date:2022-08-04

Topics:

Authors:

Auberson, Yves P.

Acklin, Pierre

Bischoff, Serge

Moretti, Robert

Ofner, Silvio

Schmutz, Markus

Veenstra, Siem J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00720-3

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine- binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsa

Full text of DOI:10.1016/S0960-894X(98)00720-3

Products guided by the article

Product name:[(R)-1-(Benzyloxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid dimethyl ester

Cas No:223647-45-8

R&D Labs maybe for 223647-45-8

Huludao Tianqi Shengye Chemical Co.,Ltd.

Contact:0086 429 2075777

Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Phantom-pharma

Contact:

Address:
Guangzhou Probig Fine Chemical Co., Ltd.

Contact:020-86297874

Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China
Allicon Pharmaceuticals,Inc.

Contact:+86-519-86339586，13584329896

Address:Changzhou Scientific and Education Park
Beijing Green Guardee Technology CO,.LTD

Contact:+86-10-69706062

Address:F2 BLdj,5 No.37 Chaoqian Road

Relevant to this article

Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4- (isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2-carbamates, and related derivatives

Doi:10.1021/jm00076a012
(1993)
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

Doi:10.1021/jacs.5b11814
(2015)
New findings in photochemistry of p-nitrophenyl azide in the presence of an amine: Generation and trapping of enamines

Doi:10.1246/cl.1999.597
(1999)
Application of neutral iridium(I) N-heterocyclic carbene complexes in ortho-directed hydrogen isotope exchange

Doi:10.1002/jlcr.3084
(2013)
Reaction of aminocarbene complexes of chromium with alkynes. 2. Intramolecular insertions leading to polycyclic lactams

Doi:10.1021/ja00076a015
(1993)
Electrostatic and electrophilic catalysis in the reductive cleavage of alkyl aryl ethers. The influence of ion pairing on the regioselectivity

Doi:10.1021/jo991059v
(2000)

Article Doi