N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists

DOI: 10.1016/S0960-894X(98)00720-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 249 - 254 (1999)

Update date:2022-08-04

Topics:

Authors:

Auberson, Yves P.

Acklin, Pierre

Bischoff, Serge

Moretti, Robert

Ofner, Silvio

Schmutz, Markus

Veenstra, Siem J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00720-3

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine- binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsa

Full text of DOI:10.1016/S0960-894X(98)00720-3

Products guided by the article

Product name:[(R)-1-(Benzyloxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid dimethyl ester

Cas No:223647-45-8

R&D Labs maybe for 223647-45-8

JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Simagchem Corporation

website:http://www.simagchem.com

Contact:+86-592-2680277

Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)

Contact:18957018777 +86-570-3888777

Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Henan Techway Chemical Co.,Ltd.

website:http://www.techwaychem.com

Contact:+86-371-66380080

Address:No.27 Shunhe Road,
Angel Yeast Co., Ltd.

Contact:+86-717-6370352

Address:168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China

Relevant to this article

Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4- (isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2-carbamates, and related derivatives

Doi:10.1021/jm00076a012
(1993)
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

Doi:10.1021/jacs.5b11814
(2015)
New findings in photochemistry of p-nitrophenyl azide in the presence of an amine: Generation and trapping of enamines

Doi:10.1246/cl.1999.597
(1999)
Application of neutral iridium(I) N-heterocyclic carbene complexes in ortho-directed hydrogen isotope exchange

Doi:10.1002/jlcr.3084
(2013)
Reaction of aminocarbene complexes of chromium with alkynes. 2. Intramolecular insertions leading to polycyclic lactams

Doi:10.1021/ja00076a015
(1993)
Electrostatic and electrophilic catalysis in the reductive cleavage of alkyl aryl ethers. The influence of ion pairing on the regioselectivity

Doi:10.1021/jo991059v
(2000)

Article Doi