Asymmetric induction in [1+4] cycloadditions of vinyl isocyanates with chiral nucleophilic carbenes

Article abstract of DOI:10.1016/S0040-4039(99)00280-4

Several chirally-modified nucleophilic carbenes afford useful levels of asymmetric induction during [1+4] cycloaddition with vinyl isocyanate reaction partners. Carbenes derived from the 1,2-aminoalcohols (1R,2S)- ephedrine and (1R,2S)-methylaminoindanol proved to be the most effective for delivering high levels of asymmetric induction.