Asymmetric synthesis of polyfunctionalized piperidines: Substitution at the C-4 position

Article abstract of DOI:10.1016/S0040-4039(99)00625-5

The electrochemical bis-bromination of the chiral building block I followed by a dehydrobromination step allowed the preparation of a bromopiperideine 3. The stereoselective addition of nucleophiles onto this key intermediate permitted the synthesis of va