Partial synthesis of ciguatoxin (5R)-ABC segment

Article abstract of DOI:10.1016/S0040-4039(99)00041-6

An ABC segment of ciguatoxin has been synthesized in a correct enantiomeric form from a D-glucose derivative based on the route for the opposite enantiomer by switching enantiomerism of a pseudosymmetric intermediate. This route, however, has been improved in several steps and ended up with a vinylthioether group for future extension toward the D ring of ciguatoxin molecule.