Journal of Medicinal Chemistry p. 129 - 138 (2007)
Update date:2022-08-03
Topics:
Clasby, Martin C.
Chackalamannil, Samuel
Czarniecki, Michael
Doller, Dario
Eagen, Keith
Greenlee, William
Kao, Grace
Lin, Yan
Tsai, Hsingan
Xia, Yan
Ahn, Ho-Sam
Agans-Fantuzzi, Jacqueline
Boykow, George
Chintala, Madhu
Foster, Carolyn
Smith-Torhan, April
Alton, Kevin
Bryant, Matthew
Hsieh, Yunsheng
Lau, Janice
Palamanda, Jairam
The metabolism of our prototypical thrombin receptor antagonist 1, K i = 2.7 nM, was studied and three major metabolites (2, 4, and 5) were found. The structures of the metabolites were verified independently by synthesis. Compound 4 was shown
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