Stereoselective synthesis of isoflavonoids. (R)- and (S)-isoflavans

Article abstract of DOI:10.1016/S0040-4020(98)01147-8

α-Benzylation of (+)- and (-)-N-phenylacetyl imidazolidinones with 2- O-methoxy-methylbenzyl bromides, followed by reductive removal of the chiral auxiliary and cyclization, afforded oxygenated isoflavans in excellent enantiomeric excess and yield.