A racemization-free coupling method for peptides having N-methylamino acids at the carboxy-termini

DOI: 10.1248/cpb.47.576

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 576 - 578 (1999)

Update date:2022-08-05

Topics:

Authors:

Nishiyama, Yasuhiro

Tanaka, Masaru

Saito, Shoubu

Ishizuka, Sou

Mori, Tomonori

Kurita, Keisuke

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Article abstract of DOI:10.1248/cpb.47.576

To search for racemization-free coupling conditions for peptides having N-alkylamino acids at the carboxy-termini, a model coupling using Boc-Phe- MeAla-OH (MeAla, N-methylalanine) and H-Phe-OBzl was studied. When benzotriazolyl-N-oxytris(dimethylamino)ph

Full text of DOI:10.1248/cpb.47.576

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