Antimalarial artemisinin analogs. Synthesis via chemoselective C-C bond formation and preliminary biological evaluation

DOI: 10.1016/S0040-4020(98)01170-3

Source and publish data:

Tetrahedron p. 3625 - 3636 (1999)

Update date:2022-08-03

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Authors:

O'Dowd, Hardwin

Ploypradith, Poonsakdi

Suji, Xie

Shapiro, Theresa A.

Posner, Gary H.

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Article abstract of DOI:10.1016/S0040-4020(98)01170-3

The peroxide bond in artemisinin trioxane lactone (1) withstood exposure to lithiothiazole and to lithiobenzothiazole; nucleophilic addition of these powerful organometallic reagents to only the lactone carbonyl group was observed. Likewise, trioxane alde

Full text of DOI:10.1016/S0040-4020(98)01170-3

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