Asymmetric synthesis of seven-carbon segments of the phorboxazoles and (-)-discodermolide: Complementary route from racemic trans-2,4-dimethyl-8- oxabicyclo[3.2.1]oct-6-en-3-one

Article abstract of DOI:10.1016/S0040-4020(99)00127-1

The C20-C26 segment of the phorboxazoles A and B and the C1-C7 segment of (-)-discodermolide were synthesized in excellent chemical and optical yield using trans-2,4-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one rac-1 with four stereogenic centres and three