Bioorganic and Medicinal Chemistry Letters p. 925 - 930 (1999)
Update date:2022-08-03
Topics:
Dominguez, Celia
Duffy, Daniel E.
Han, Qi
Alexander, Richard S.
Galemmo Jr., Robert A.
Park, Jeongsook M.
Wong, Pancras C.
Amparo, Eugene C.
Knabb, Robert M.
Luettgen, Joseph
Wexler, Ruth R.
Thrombin, a serine protease, plays a central role in the initiation of thrombotic events. We report design, synthesis, and antithrombotic efficacy of XU817 (7), a nonpeptide 5-(amidino) indole thrombin inhibitor. Utilizing the co-crystal structure of XU817 bound in the active site of thrombin we were able to synthesize analogs with enhanced thrombin affinity.
View MoreYuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD
Contact:86-0951-7815345
Address:North side of Qiyuan Road, west side of Yuanfeng Highway, New Material Park, Ningdong Energy and Chemical Industry Base, Ningxia,China
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-66880623
Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA
Contact:0572-2722882
Address:1201,F3,xinghuibandao,
Doi:10.1016/j.tetasy.2013.12.001
(2014)Doi:10.1016/j.ejmech.2015.05.025
(2015)Doi:10.1139/v71-260
(1971)Doi:10.3987/COM-94-S(B)82
(1994)Doi:10.1039/DT9930003359
(1993)Doi:10.1039/c39940000081
(1994)
