Synthesis of chiral 1,4-dihydropyridines by diastereoface-selective asymmetric addition to nicotinic amides

Article abstract of DOI:10.1016/S0040-4039(99)00683-8

Diastereoface-selective asymmetric addition of organometallic reagents to pyridinium salts of 1 and 2 was performed to give chiral 1,4-dihydropyridines in good regio- and stereoselectivities. The absolute configuration of the newly-produced chiral center