Chiral syntheses of 2,3,5-trisubstituted pyrrolidines by silicon-directed cyclization of allylsilanes bearing a sulfonamide moiety

Article abstract of DOI:10.1016/S0040-4039(99)00680-2

Bronsted acid-catalyzed cyclization of chiral N-tosyl-3-silyl-4-pentenamine proceeded smoothly by way of a β-silyl carbocation intermediate to furnish 2,3,5-trisubstituted pyrrolidines in enantiomerically pure form.