Controlled monohalogenation of phosphonates: A new route to pure α- monohalogenated diethyl benzylphosphonates

Article abstract of DOI:10.1016/S0040-4020(99)00037-X

Starting from diethyl benzylphosphonates, a wide variety of diethyl α- monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCI followed by halogenation with an electrophilic halogenating reagent.